![]() ConclusionsĮven in healthy subjects without metabolic syndrome increasing triglyceride levels within the normal range confer a continuous increase in type 2 diabetes incidence. Cox regression confirmed a significant prospective association independent of HOMA-IR and several other recognized risk factors. In Kaplan-Meier analysis sex-stratified tertiles of normal triglycerides prospectively associated with de novo type 2 diabetes (p < 0.001). In linear regression analysis baseline insulin, HOMA-IR, total cholesterol, HDL cholesterol, eGFR, systolic blood pressure (all p < 0.001), glucose, age and creatinine (all p < 0.01) independently associated with triglycerides within the normal range, comparable to what would be expected from associations with increased triglycerides. Incident type 2 diabetes was determined in healthy individuals with normal triglyceride levels from a prospective longitudinal cohort study (PREVEND, n = 2085, 11.4-year median follow-up). We investigated whether also normal triglycerides prospectively associate with incident type 2 diabetes in healthy subjects. Traditionally, only hypertriglyceridemia is considered a risk factor. GHNHSFT Guidelines: Guidelines on Statin Prescribing in Prevention of CVD.Type 2 diabetes is increasing worldwide. Further informationĬholesterol monograph of the Association for Clinical Biochemistry and Laboratory Medicine Reference ranges are not quoted for the other lipid profile parameters, rather results should be assessed in terms of the overall risk to the patient. Reference range for fasting serum triglyceride: 0.6 - 1.9 mmol/L The in-lab turnaround time is less than 24 hours. The assays are run throughout the day and night. Please state whether patient fasting or not at time of venepuncture. Relevant clinical details including current lipid medication any family history. If unavoidable, samples can be stored refrigerated overnight. ![]() Send at ambient temperature to the laboratory. Sample requirementsįor a Full Fasting Lipid Profile, a blood sample collected after a 12 - 14 hour fast is required.įor adults, blood taken into a 5mL gold top tube (or rust top for the Acute Unit)įor children, blood taken into a 3.5mL rust top tubeįor neonates, blood taken into a 0.8mL minicollect lithium heparin tube Therefore a normal cholesterol result during this period does not necessarily exclude hypercholesterolaemia. HDL-cholesterol is not reported if triglyceride levels are >20mmol/L.Ĭholesterol levels fall within 24 hours of an acute myocardial infarction and return to pre-infarction levels over the following three months. LDL-cholesterol is not reported in non-fasting samples or if triglyceride levels are >4.5mmol/L. Follow up investigation of hypertriglyceridaemia or investigation of possible familial hypercholesterolaemia identified at screening - chiolesterol, HDL-cholesterol, cholesterol:HDL-cholesterol ratio, non HDL-cholesterol, triglycerides, LDL-cholesterol (12 - 14 hour fast required) (Full Fasting Lipid Profile).Baseline pre-treatment profile in the NICE guideline - cholesterol, HDL-cholesterol, non HDL-cholesterol, cholesterol:HDL-cholesterol ratio and triglyceride (fasting not required) (Full Non-Fasting Lipid Profile).Initial CVD risk-assessment and monitoring of statin medication in patients at increased risk of CVD - cholesterol, HDL-cholesterol, cholesterol:HDL-cholesterol ratio and non HDL-cholesterol (fasting not required) (Non-Fasting Cholesterol Test).Total cholesterol: HDL-Cholesterol ratio.LDL-cholesterol (calculated requires a fasting blood sample).
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